In order to investigate the effects of Tongyujian on thrombosis and elevated blood viscosity, rats injected endotoxin into the caudal vein to make experimental thrombosis model were orally administrated solid extract of Tongyujian 520mg/200g, and
then
observed platelet, fibrinogen, prothrombin time and FDP level.
Another group injected hydrocortisone acetate into the muscular rump to make experimental elevated blood viscosity model were orally administrated Tongyujian, thereafter measured whole blood viscosity and plasma viscosity.
@ES The results were summarized as follows.
@EN 1. Platelet was decreased significant in sample compared with the control group.
2. Fibrinogen level was increased in sample compared with the control group.
3. Prothrombin time was shortended in sample compared with the control group.
4. FDP was decreased significantly in sample compared with the control group.
5. Whole blood viscosity and plasma viscosity were decreased significantly in sample compared with the control group.
According to the above results, it is considered that Tongyujian has effects on platelets, fibrinogen, prothrombintime, FDP, whole blood viscosity, therefore it seems of be applicable to disease related to thrombosis, hemorrhage and blood
viscosity.
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